Anti-LASV GPC Antibody (2.9D) (VK453093)

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50ug
100ug
1mg

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Datasheet

Overview

Catalog No.

VK453093

Description

Anti-LASV GPC Antibody (2.9D) [2.9D] (VK453093) is a human monoclonal antibody detecting GPC in ELISA, Neutralization.

Species reactivity

Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)

Applications

ELISA, Neutralization

Host species

Human

Isotype

IgG1, kappa

Clone ID

2.9D

Clonality

Monoclonal

Target

Pre-glycoprotein polyprotein GP complex, Pre-GP-C, GPC, GP-C

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P08669

RRID

Anti-LASV GPC Antibody (2.9D) (abinScience Cat# VK453093, RRID:AB_3725217)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Pre-glycoprotein polyprotein GP complex (GPC) is a ~55 kDa protein. Functions as a cleaved signal peptide that is retained as the third component of the GP complex (GP-C). Helps to stabilize the spike complex in its native conformation. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of G1 and G2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.

1. Katz, M. et al. (2022) Nature 603, 174-179. PMID: 35173332

2. Eichler, R. et al. (2003) EMBO reports 4, 1084-8. PMID: 14555961

Note

For research use only.

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