Anti-LASV GPC antibody (Fab 37.7) (VK453013)

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Datasheet

Overview

Catalog No.

VK453013

Description

Anti-LASV GPC antibody (Fab 37.7) [Fab 37.7] (VK453013) is a human monoclonal antibody detecting GPC in ELISA, WB. Suitable for Lassa virus (LASV).

Species reactivity

Lassa virus (LASV)

Applications

ELISA, WB

Host species

Human

Isotype

IgG1, lambda

Clone ID

Fab 37.7

Clonality

Monoclonal

Target

Pre-glycoprotein polyprotein GP complex, Pre-GP-C, GPC, GP-C

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P08669

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Pre-glycoprotein polyprotein GP complex (GPC) is a ~55 kDa protein. Functions as a cleaved signal peptide that is retained as the third component of the GP complex (GP-C). Helps to stabilize the spike complex in its native conformation. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of G1 and G2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.

1. Katz, M. et al. (2022) Nature 603, 174-179. PMID: 35173332

2. Eichler, R. et al. (2003) EMBO reports 4, 1084-8. PMID: 14555961

Note

For research use only.

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