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Recombinant Human LTK Protein, N-His (HB966012)

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Overview

Catalog No.	HB966012
Description	Recombinant Human LTK Protein, N-His (HB966012) expressed in E. coli, spanning Ser67-Asn380. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P29376
Protein length	Ser67-Asn380
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	33.6 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.10.1, LTK, Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, TYK1
Background	Leukocyte tyrosine kinase receptor is a ~91 kDa protein. Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. 1. Honda, H. et al. (1999) Oncogene 18, 3821-30. PMID: 10445845 2. Farhan, H. et al. (2010) The Journal of cell biology 189, 997-1011. PMID: 20548102 3. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385 4. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012 5. Yamada, S. et al. (2008) Neuroreport 19, 1733-8. PMID: 18849880 6. Ueno, H. et al. (1997) Oncogene 14, 3067-72. PMID: 9223670
Note	For research use only

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Datasheet

Recombinant Human LTK Protein, N-His.pdf

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Recombinant Human LTK Protein, N-His