Anti-Human LTK Polyclonal Antibody (HB966014)

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100ug

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Datasheet

Overview

Catalog No.

HB966014

Description

Anti-Human LTK Polyclonal Antibody (HB966014) is a rabbit polyclonal antibody detecting LTK. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human LTK (Ser67-Asn380).

Target

EC:2.7.10.1, LTK, Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, TYK1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P29376

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Leukocyte tyrosine kinase receptor (LTK) is a ~91 kDa protein. Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival.

1. Honda, H. et al. (1999) Oncogene 18, 3821-30. PMID: 10445845

2. Farhan, H. et al. (2010) The Journal of cell biology 189, 997-1011. PMID: 20548102

3. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385

4. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012

5. Yamada, S. et al. (2008) Neuroreport 19, 1733-8. PMID: 18849880

6. Ueno, H. et al. (1997) Oncogene 14, 3067-72. PMID: 9223670

Note

For research use only

Images

Western blot

Western blot analysis was performed using anti-LTK polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: HL-60 cell lysate
Lane 3: THP-1 cell lysate

References

Datasheet

Anti-Human LTK Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human LTK Polyclonal Antibody (HB966014)

Overview

Images

References

Datasheet

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