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Anti-Human CD93/C1qR Antibody (070-016), FITC (HV345117)

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Anti-Human CD93/C1qR Antibody (070-016), FITC

Anti-Human CD93/C1qR Antibody (070-016), FITC

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Datasheet

Overview

Catalog No.	HV345117
Description	Anti-Human CD93/C1qR Antibody (070-016), FITC [070-016] (HV345117) is a mouse monoclonal antibody detecting C1qR(p) in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	070-016
Conjugation	FITC
Clonality	Monoclonal
Target	Matrix-remodeling-associated protein 4, C1q/MBL/SPA receptor, C1qRp, C1QR1, C1qR, Complement component 1 q subcomponent receptor 1, CD93, Complement component C1q receptor, MXRA4, CDw93, C1qR(p)
Endotoxin level	Please contact with the lab for this information.
Accession	Q9NPY3
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Complement component C1q receptor (CD93/C1qR) is a ~68 kDa protein. Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. 1. Geertsma, MF. et al. (1994) The American journal of physiology 267, L578-84. PMID: 7977768 2. Orlandini, M. et al. (2014) Oncotarget 5, 2750-60. PMID: 24809468 3. Galvagni, F. et al. (2016) Oncotarget 7, 10090-103. PMID: 26848865 4. Khan, KA. et al. (2017) Oncogene 36, 6097-6108. PMID: 28671670 5. Barbera, S. et al. (2023) International journal of biological macromolecules 224, 453-464. PMID: 36265539 6. Xu, Y. et al. (2024) Structure (London, England : 1993) 32, 282-291.e4. PMID: 38218180
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Images

Flow CytoMetry

Flow-cytometry using FITC anti-human CD93 antibody. U937 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human CD93 monoclonal antibody (Catalog: HV345117, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet

Anti-Human CD93/C1qR Antibody (070-016), FITC.pdf

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Anti-Human CD93/C1qR Antibody (070-016), FITC