Anti-Human CD93/C1qR Antibody (070-016) (HV345107)

Name: Anti-Human CD93/C1qR Antibody (070-016)
Brand: abinScience
SKU: HV345107
Price: 191 USD
Availability: InStock

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Overview
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Datasheet

Overview

Catalog No.	HV345107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	070-016
Clonality	Monoclonal
Target	Matrix-remodeling-associated protein 4, C1q/MBL/SPA receptor, C1qRp, C1QR1, C1qR, Complement component 1 q subcomponent receptor 1, CD93, Complement component C1q receptor, MXRA4, CDw93, C1qR(p)
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NPY3
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Complement component C1q receptor (CD93/C1qR) is a ~68 kDa protein. Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (1). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (2). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration (3). References: 1. Geertsma, MF. et al. (1994) The American journal of physiology 267, L578-84. PMID: 7977768 2. Orlandini, M. et al. (2014) Oncotarget 5, 2750-60. PMID: 24809468 3. Galvagni, F. et al. (2016) Oncotarget 7, 10090-103. PMID: 26848865 4. Khan, KA. et al. (2017) Oncogene 36, 6097-6108. PMID: 28671670 5. Barbera, S. et al. (2023) International journal of biological macromolecules 224, 453-464. PMID: 36265539 6. Xu, Y. et al. (2024) Structure (London, England : 1993) 32, 282-291.e4. PMID: 38218180
Note	For research use only.

Images

SEC-HPLC

SEC-HPLC detection for Anti-Human CD93/C1qR Antibody (070-016).
Bioactivity

Detects CD93/C1qR in indirect ELISAs.
Flow Cytometry

Flow-cytometry using anti-human CD93 antibody. Human U-937 cell line were stained with an irrelevant antibody (Green Histogram) or an anti-human CD93 antibody monoclonal antibody (Catalog # HV345107 , Red Histogram) at a concentration of 20 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a CoraLite488 conjugated goat anti-mouse antibody (Catalog # MF690314) and cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using anti-human CD93 antibody. U937 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD93 monoclonal antibody (Catalog: HV345107, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Mouse IgG H&L Polyclonal Antibody, FITC (abinScience: MF690414) and cells analysed on a NovoCyte Flow Cytometer.