Anti-Human papillomavirus type 16 E6/Protein E6 Nanobody (SAA1338) (VK451023)

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Datasheet

Overview

Catalog No.

VK451023

Description

Anti-Human papillomavirus type 16 E6/Protein E6 Nanobody (SAA1338) [SAA1338] (VK451023) is a alpaca monoclonal antibody detecting Protein E6 in ELISA, IF, WB.

Highlights

●Multi-Application — Validated across multiple applications.

Species reactivity

Human papillomavirus type 16

Applications

ELISA, IF, WB

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clone ID

SAA1338

Clonality

Monoclonal

Target

Protein E6, E6

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P03126

RRID

Anti-Human papillomavirus type 16 E6/Protein E6 Nanobody (SAA1338) (abinScience Cat# VK451023, RRID:AB_3726811)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Protein E6 is a ~19 kDa protein. Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).

Note

For research use only.

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