Dog Anti-RABV G/Glycoprotein Antibody (SAA2224) (VK632103)

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Spec:

50ug
100ug
1mg

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Overview
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Datasheet

Overview

Catalog No.

VK632103

Description

Dog Anti-RABV G/Glycoprotein Antibody (SAA2224) [SAA2224] (VK632103) is a dog monoclonal antibody detecting Glycoprotein in ELISA, Neutralization, WB. Suitable for Rabies virus (RABV).

Highlights

●Multi-Application — Validated across multiple applications.

Species reactivity

Rabies virus (RABV)

Applications

ELISA, Neutralization, WB

Host species

Dog

Isotype

IgG2, lambda

Clone ID

SAA2224

Clonality

Monoclonal

Target

Glycoprotein, G

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O92284, P08667

RRID

Dog Anti-RABV G/Glycoprotein Antibody (SAA2224) (abinScience Cat# VK632103, RRID:AB_3729707)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Glycoprotein is a ~58 kDa protein. Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.

Note

For research use only.

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