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Research Grade Cinrebafusp alfa (HC336186)

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100ug
1mg

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Datasheet

Overview

Catalog No.	HC336186
Species reactivity	Human
Applications	Research Grade Biosimilar
Host species	Human
Isotype	IgG
Expression system	Mammalian Cells
Target	Bispecific, Tumor necrosis factor receptor superfamily member 9, CD137, 4-1BB ligand receptor, CDw137, TNFRSF9, T-cell antigen ILA, T-cell antigen 4-1BB homolog, ILA, p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein
Concentration	1mg/ml
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G, purified from cell culture supernatant.
Accession	Q07011 & P04626
Form	Liquid
Storage buffer	0.01M PBS,pH7.4.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -2469°C.
Background	Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.
Note	For research use only. Not for use in clinical or therapeutic applications.

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References

Datasheet

Research Grade Cinrebafusp alfa.pdf

Recommendation

Research Grade Anti-Human CD137/TNFRSF9/4-1BB & CD340/ERBB2/HER2 (PRS-343)

Research Grade Cinrebafusp alfa