Research Grade Tanezumab (HF909016)

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100ug
1mg

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Overview

Catalog No.	HF909016
Description	Research Grade Tanezumab (HF909016) is a humanized monoclonal antibody detecting Beta-nerve growth factor in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG2-kappa
Expression system	Mammalian Cells
Species	Human
Clonality	Monoclonal
Target	Beta-nerve growth factor, NGFB, Beta-NGF, NGF
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P01138
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternate Names	PF-04383119, RN624, 880266-57-9
Background	Beta-nerve growth factor (Beta-nerve growth factor,NGFB,Beta-NGF,NGF) is a ~26 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. 1. Einarsdottir, E. et al. (2004) Human molecular genetics 13, 799-805. PMID: 14976160 2. Carvalho, OP. et al. (2011) Journal of medical genetics 48, 131-5. PMID: 20978020 3. Wijeyewickrema, LC. et al. (2010) The Journal of biological chemistry 285, 11793-9. PMID: 20164177
Note	For research use only. Not suitable for clinical or therapeutic use.