| Catalog No. | HB771016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Species | Human |
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| Clonality | Monoclonal |
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| Target | T-cell growth factor P40, Cytokine P40, IL9, Interleukin-9, IL-9 |
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| Endotoxin level | Please contact with the lab for this information. |
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| Purity | >95% as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P15248 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
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| Alternate Names | 7F3com-2H2, MEDI-528, 909875-08-7 |
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| Background | Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways.
• IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion., PMID:38941612
• Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development., PMID:39164066
• The Role of Interleukin-9 in Cancer., PMID:31016637
• IL-9, a local growth factor for synovial T cells in inflammatory arthritis., PMID:26751012
• Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease., PMID:38825637
• Interleukin-9 and mast cells., PMID:23034251
• IL-9 sensitizes human TH2 cells to proinflammatory IL-18 signals in atopic dermatitis., PMID:39521283
• IL-9 and IL-9-producing cells in tumor immunity., PMID:32228589
• Interleukin-9 and T helper type 9 cells in rheumatic diseases., PMID:27159882
• IL-9-producing T cells: potential players in allergy and cancer., PMID:32788707
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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