| Catalog No. | VK515096 |
|---|
| Description | CR8020 is a broadly neutralizing antibody (bNAb) targeting the stem region of influenza A virus (IAV) hemagglutinin (HA) and is in phase II trials for prophylactic use against group 2 IAVs. Structural and computational analyses show that CR8020 binds HA residues subject to antigenic drift and host selection pressure, with escape mutations observed in some H7N9 strains. Additionally, effective engagement of Fcγ receptors (FcγR) is crucial for antibody efficacy, but membrane steric hindrance may limit HA-CR8020-FcγR complex formation. These findings highlight epitope mutability and immune complex accessibility as key factors in bNAb development. |
|---|
| Species reactivity | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Human |
|---|
| Isotype | IgG1-lambda |
|---|
| Clone ID | CR8020 |
|---|
| Expression system |
Mammalian Cells |
| Target |
Hemagglutinin, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, HA |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
Q91MA7 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Note |
For research use only. Not suitable for clinical or therapeutic use. |
