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Research Grade arcotatug (HX126296)

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Research Grade arcotatug

Research Grade arcotatug

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100ug
1mg

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Datasheet

Overview

Catalog No.	HX126296
Description	arcotatug (HX126296) is a research-grade recombinant antibody targeting CLDN18.2. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, FACS, Functional assay
Host species	Human
Isotype	IgG1, kappa
Clonality	Monoclonal
Target	CLDN18.2
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE
Purification	Protein A/G purified from cell culture supernatant.
Accession	P56856
Form	Liquid
Storage buffer	0.01 M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternate Names	CAS: 3031170-61-0
Background	Claudin-18 is a ~27 kDa protein. Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling. Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier. Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription. Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency. Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways.
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Research Grade arcotatug

References

Datasheet

Research Grade arcotatug.pdf

Formula

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Research Grade arcotatug