| Catalog No. | HA097016 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Isotype | Human ROBO2 fragment (1-203), fused to human IgG1 Fc fragment |
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| Expression system | Mammalian Cells |
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| Target | Roundabout homolog 2, KIAA1568, ROBO2 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q9HCK4 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2760175-31-1 |
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| Background | Sifarobocept is a recombinant fusion protein comprising an roundabout guidance receptor 2 (ROBO2) fused to a human IgG1 Fc.
• Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure., PMID:32220420
• Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding., PMID:35940226
• Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2., PMID:30700556
• Function of Slit/Robo signaling in breast cancer., PMID:26542734
• Genome-Wide Association Study Identifies ROBO2 as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors., PMID:36508697
• Down-regulation of ROBO2 expression in prostate cancers., PMID:24272677
• Structural Principles in Robo Activation and Auto-inhibition., PMID:30853216
• ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma., PMID:34148491
• An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations., PMID:35584116
• Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications., PMID:19104841
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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