| Catalog No. | CV121016 |
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| Species reactivity | Dog |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Dog |
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| Isotype | IgG2-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | IL31RA |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | A0A8I3Q391 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2750248-93-0 |
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| Background | Nolavetbart is an anti-Canlupfam IL31RA human IgG2 κ monoclonal antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).
• Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching., PMID:38035099
• Nemolizumab: First Approval., PMID:35834124
• IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis., PMID:37831760
• Interleukin-31: The "itchy" cytokine in inflammation and therapy., PMID:33629401
• Phase 3 Trial of Nemolizumab in Patients with Prurigo Nodularis., PMID:37888917
• Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics., PMID:36646705
• Prurigo nodularis: new insights into pathogenesis and novel therapeutics., PMID:38345154
• Mechanisms and treatments of neuropathic itch in a mouse model of lymphoma., PMID:36520531
• A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1., PMID:24373353
• Genetic association of IL2RA, IL17RA, IL23R, and IL31RA single nucleotide polymorphisms with alopecia areata., PMID:36248775
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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