| Catalog No. | JN085016 |
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| Species reactivity | Clostridioides difficile |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Toxin A/tcdA |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P16154 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | CDA1, MBL-CDA1, MDX-066, MK-3415A(combinationofactoxumabandbezlotoxumab), 1245634-25-6 |
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| Background | Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB.
• A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile., PMID:27770789
• Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis., PMID:38922136
• The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins., PMID:26633511
• The enterotoxicity of Clostridium difficile toxins., PMID:22069662
• Comparative biofilm-forming ability between Clostridioides difficile strains isolated in Latin America and the epidemic NAP1/027 strain., PMID:36619751
• The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study., PMID:24708941
• [Effects of Tcd A on Rho GTPases and the Cytoskeleton of Leukemia Cell Line K562]., PMID:30295246
• [Using the real-time PCR assay to establish TaqMan-MGB probe for rapid identification of Clostridium difficile and its toxin]., PMID:25059372
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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