| Catalog No. | VK632036 |
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| Species reactivity | Rabies virus (RABV) |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1, kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
G, Glycoprotein |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
O92284, P08667 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | CTB012, CTB-012, CTB012, SYN023, CAS: 2419087-89-9 |
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| Background | Mazorelvimab (SYN023) is a combination of CTB011 and CTB012 humanized monoclonal antibodies cocktail against rabies virus (RABV). Mezagitamab binds to non-overlapping epitopes on RABV glycoprotein (G). Mezagitamab has potential application in the prevention of rabies.
• The glycoprotein G of rhabdoviruses., PMID:7605197
• Chandipura viral glycoprotein (CNV-G) promotes Gectosome generation and enables delivery of intracellular therapeutics., PMID:38702887
• The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism., PMID:32937107
• Viral membrane fusion: is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins?, PMID:15933774
• G glycoprotein amino acid residues required for human monoclonal antibody RAB1 neutralization are conserved in rabies virus street isolates., PMID:21693135
• Structure and Dynamics of Immunoglobulin G Glycoproteins., PMID:30484251
• Chemical-Synthesis-Based Approach to Glycoprotein Functions in the Endoplasmic Reticulum., PMID:33107166
• Human metapneumovirus glycoprotein G disrupts mitochondrial signaling in airway epithelial cells., PMID:23626834
• Boronic acid functionalized g-C3N4 nanosheets for ultrasensitive and selective sensing of glycoprotein in the physiological environment., PMID:29480294
• 4'-(8-(4-Methylimidazole)-octyloxy)-arctigenin: The first inhibitor of fish rhabdovirus glycoprotein., PMID:37385462
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
