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Research Grade Ivonescimab (HB941056)

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Spec:
  • 100ug
  • 1mg
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  • Datasheet
Overview
Catalog No.HB941056
Species reactivityHuman
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host speciesHumanized
IsotypeIgG1-kappa-[scFv]2
Expression system Mammalian Cells
Clonality Monoclonal
Target Vascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A, Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
Endotoxin level Please contact the lab for this information.
Purity >95% purity as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P15692 & Q15116
Form Liquid
Storage buffer 0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate NamesTetravalentBispecific, AK112, AK-112, AK1122428381-53-5
BackgroundIvonescimab (AK112) is a PD-1/VEGF Bispecific Antibody. Ivonescimab can be used for cancer research.
Note For research use only. Not suitable for clinical or therapeutic use.
Images
  • Bioactivity

    Detects VEGF165 in indirect ELISA.

  • Bioactivity

    Detects recombinant human PD1 (Cat No.: HS870021) in indirect ELISA.

  • Flow CytoMetry

    Flow-cytometry using FITC anti-human VEGFA&PD1 antibody. U87 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human VEGFA&PD1 monoclonal antibody (Catalog: HB941056, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

  • Western blot

    Western blot analysis was performed using anti-VEGFA/VEGF165 monoclonal antibody at 1ug/mL on various samples.
    Lane 1: recombinant human VEGFA/VEGF165 (Catalog No: HB941011)
    Lane 2: negative control

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