| Catalog No. | HX206026 |
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| Description | MEDI3185haspicomolarbindingaffinitytohumanCXCR4andexhibitsnosignificantbindingtootherchemokinereceptorssuchasCCR4orCXCR3.InvitrostudiesdemonstratedthatMEDI3185inhibitedtumorcellmigration,blockedSDF-1inducedtumorcellsignalingandinducedapoptosisoftumorcells.TheMEDI3185epitopecomprisestheentireECL2sequence,lacksanyso-called'hot-spot'andisremarkablyresistanttomutations.ThestructureofMEDI3185variabledomainswasmodeled,andsuggestedaβ-strand/β-strandinteractionbetweenMEDI3185CDR3HandCXCR4ECL2,resultingindirectsterichindrancewithCXCR4ligandSDF-1. |
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| Species reactivity | Human |
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| Applications | Research Grade Biosimilar |
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| Host species | Human |
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| Isotype | IgG1 |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Stromal cell-derived factor 1 receptor, LCR1, HM89, LPS-associated protein 3, LAP-3, CXC-R4, CXCR-4, SDF-1 receptor, CD184, NPYRL, LESTR, Fusin, FB22, C-X-C chemokine receptor type 4, CXCR4, Lipopolysaccharide-associated protein 3, Leukocyte-derived seven transmembrane domain receptor |
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| Concentration | 1mg/ml |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G, purified from cell culture supernatant. |
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| Accession | P61073 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS,pH7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -720°C. |
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| Note | For research use only. Not for use in clinical or therapeutic applications. |
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