| Catalog No. | HX959046 |
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| Species reactivity | Human |
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| Applications | Research Grade Biosimilar |
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| Host species | Humanized |
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| Isotype | (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Tumor necrosis factor receptor superfamily member 17, TNFRSF17, CD269, B-cell maturation protein, BCMA, BCM, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain |
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| Concentration | 0.85mg/ml |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G, purified from cell culture supernatant. |
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| Accession | Q02223 & P07766 |
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| Form | Liquid |
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| Storage buffer | 30mM Histidine,pH5.8,10% Sucrose,0.06% Tween80. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -649°C. |
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| Alternate Names | Bispecific,AMG-420,AMG420,BI-836909,CAS:2251756-52-0 |
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| Background | Pacanalotamab (AMG 420; BI-836909) is a bispecific T-cell engager (BiTE) targeting to BCMA and CD3E. BCMA refers to B cell maturation antigen, as Pacanalotamab redirecting T cells to BCMA expressing cells on the cell surface. Pacanalotamab conducts T-cell redirected lysis of human multiple myeloma (MM) cell lines. |
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| Note | For research use only. Not for use in clinical or therapeutic applications. |
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