| Catalog No. | VK705016 |
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| Species reactivity | Human cytomegalovirus (HCMV/HHV-5) |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1, kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
Envelope glycoprotein H, gH, gH, UL75 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
P12824 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | EV27, MSL109, SDZMSL109, 138660-96-5 |
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| Background | Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL.
• Characterization of the human cytomegalovirus UL75 (glycoprotein H) late gene promoter., PMID:12490392
• Viral shedding, and distribution of cytomegalovirus glycoprotein H (UL75), glycoprotein B (UL55), and glycoprotein N (UL73) genotypes in congenital cytomegalovirus infection., PMID:32086150
• Human cytomegalovirus envelope glycoprotein B, H, and N polymorphisms among infants of Shanghai area in China., PMID:32567060
• Cytomegalovirus glycoprotein H genotype distribution and the relationship with hearing loss in children., PMID:24615599
• The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection., PMID:9188570
• Cytomegalovirus Genetic Diversity Following Primary Infection., PMID:31593588
• Glycoprotein H of human cytomegalovirus (HCMV) forms a stable complex with the HCMV UL115 gene product., PMID:1328481
• Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally., PMID:31705022
• Characterization of a novel third member of the human cytomegalovirus glycoprotein H-glycoprotein L complex., PMID:9188610
• Expression and reconstitution of the gH/gL/gO complex of human cytomegalovirus., PMID:12361760
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
