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Research Grade Suvratoxumab (JN998026)

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Research Grade Suvratoxumab

Research Grade Suvratoxumab

Research Grade Suvratoxumab

Research Grade Suvratoxumab

Research Grade Suvratoxumab

Research Grade Suvratoxumab

Price(USD): $

Spec:

100ug
1mg

Number:

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Overview
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References
Datasheet

Overview

Catalog No.	JN998026
Description	Suvratoxumab (JN998026) is a research-grade recombinant antibody targeting Alpha-hemolysin. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Staphylococcus aureus
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Alpha-hemolysin, hly, Alpha-HL, Alpha-toxin, hla
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P09616
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	MEDI4893, 1629620-18-3
Background	Alpha-hemolysin (Alpha-toxin/hly) is a ~35 kDa protein. Alpha-toxin binds to the membrane of eukaryotic cells (particularly red blood cells, RBC) forming pores, resulting in hemolysis, with the release of low-molecular weight molecules leading to eventual osmotic RBC lysis. Human RBCs bind much less alpha-toxin than do rabbit RBCs. Heptamer oligomerization and pore formation is required for lytic activity. 1. Walker, B. et al. (1992) The Journal of biological chemistry 267, 10902-9. PMID: 1587866 2. Wilke, GA. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 13473-8. PMID: 20624979
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Suvratoxumab.
Bioactivity

Detects Alpha-toxin/hly in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Suvratoxumab.

References

Datasheet

Research Grade Suvratoxumab.pdf

Formula

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Research Grade Suvratoxumab