| Catalog No. | HB116056 |
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| Species reactivity | Human |
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| Applications | Research Grade Biosimilar |
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| Host species | Human |
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| Isotype | IgG2-lambda |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3 |
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| Concentration | 1mg/ml |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G, purified from cell culture supernatant. |
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| Accession | P21860 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS,pH7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -335°C. |
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| Alternate Names | MM-121,SAR256212,CAS:1334296-12-6 |
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| Background | Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models. |
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| Note | For research use only. Not for use in clinical or therapeutic applications. |
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