| Catalog No. | HS870046 |
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| Species reactivity | Human |
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| Applications | Research Grade Biosimilar |
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| Host species | Human |
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| Isotype | IgG4-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279 |
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| Concentration | 1mg/ml |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G, purified from cell culture supernatant. |
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| Accession | Q15116 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS,pH7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -238°C. |
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| Alternate Names | JNJ-63723283,CAS:2050478-92-5 |
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| Background | Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo. |
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| Note | For research use only. Not for use in clinical or therapeutic applications. |
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