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Anti-Human CD226/DNAM-1 Antibody (SAA0074) (HS737107)

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Anti-Human CD226/DNAM-1 Antibody (SAA0074)

Anti-Human CD226/DNAM-1 Antibody (SAA0074)

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Overview

Catalog No.	HS737107
Description	Anti-Human CD226/DNAM-1 Antibody (SAA0074) [SAA0074] (HS737107) is a mouse monoclonal antibody detecting DNAM-1 in FCM, Neutralization. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM, Neutralization
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	SAA0074
Clonality	Monoclonal
Target	DNAX accessory molecule 1, DNAM-1, DNAM1, CD226 antigen, CD226
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q15762
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	CD226 antigen (DNAM-1) is a ~38 kDa protein. Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes. 1. Shibuya, A. et al. (1996) Immunity 4, 573-81. PMID: 8673704 2. Shibuya, A. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 1671-6. PMID: 9712030 3. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705 4. Deuss, FA. et al. (2019) The Journal of biological chemistry 294, 12534-12546. PMID: 31253644 5. Wang, H. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 988-996. PMID: 30591568
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Anti-Human CD226/DNAM-1 Antibody (SAA0074)

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Datasheet

Anti-Human CD226/DNAM-1 Antibody (SAA0074).pdf

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Anti-Human CD226/DNAM-1 Antibody (SAA0074)