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InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265) (MW444020)

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InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265)

InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265)

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100ug
1mg

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Datasheet

Overview

Catalog No.	MW444020
Description	InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265) [Iv0265] (MW444020) is a mouse monoclonal antibody detecting C-C chemokine receptor type 8 in ELISA, FCM, Neutralization. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	ELISA, FCM, Neutralization
Host species	Mouse
Isotype	IgG2a, lambda
Clone ID	Iv0265
Clonality	Monoclonal
Target	C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CDw198, Ccr8, Cmkbr8, Ter1
Endotoxin level	Please contact with the lab for this information.
Purity	>95% by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P56484
RRID	InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265) (abinScience Cat# MW444020, RRID:AB_3729621)
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production. 1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461 2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588 3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265)

References

Datasheet

InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265).pdf

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InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265)