InVivoMAb Anti-SARS-CoV-2 S2 Protein Antibody (CC40.8) (VK749010)

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Спецификация:

100ug
1mg

Количество:

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Даташит

Обзор

Каталожный номер	VK749010
Описание	InVivoMAb Anti-SARS-CoV-2 S2 Protein Antibody (CC40.8) [CC40.8] (VK749010) is a human monoclonal antibody detecting S2 Protein in Neutralization.
Реактивность видов	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Применения	Neutralization
Хозяинский вид	Human
Изотип	IgG1, kappa
ID клона	CC40.8
Клоональность	Monoclonal
Цель	S2 Protein, Spike protein S2, Spike protein S2', Spike glycoprotein, S glycoprotein, E2, Peplomer protein, Spike protein S1, S
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P0DTC2
RRID	InVivoMAb Anti-SARS-CoV-2 S2 Protein Antibody (CC40.8) (abinScience Cat# VK749010, RRID:AB_3727050)
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон	Spike glycoprotein (Spike glycoprotein 2) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

Bioactivity

SEC-HPLC detection for InVivoMAb Anti-SARS-CoV-2 S2 Protein Antibody (CC40.8).
SDS-PAGE

SDS-PAGE for InVivoMAb Anti-SARS-CoV-2 S2 Protein Antibody (CC40.8).
Western blot

Western blot analysis was performed using anti-SARS-CoV-2 S2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant SARS-CoV-2 S2/Spike S2 (ECD) (Catalog No: VK749032)
Lane 2: negative control
Bioactivity

Detects recombinant SARS-CoV-2 S2/Spike S2 (ECD) (Catalog No: VK749032) in indirect ELISA