Anti-Human BMP6 Antibody (SAA0425), PerCP (HB857147)

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Overview

Catalog No.	HB857147
Description	Anti-Human BMP6 Antibody (SAA0425), PerCP [SAA0425] (HB857147) is a mouse monoclonal antibody detecting BMP6 in ELISA, FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0425
Conjugation	PerCP
Clonality	Monoclonal
Target	VG-1-R, VG-1-related protein, Bone morphogenetic protein 6, VGR-1, BMP-6, VGR, BMP6
Endotoxin level	Please contact with the lab for this information.
Accession	P22004
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Bone morphogenetic protein 6 (BMP6) is a ~57 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. 1. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025 2. Daher, R. et al. (2016) Gastroenterology 150, 672-683.e4. PMID: 26582087 3. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509 4. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 5. Saremba, S. et al. (2008) The FEBS journal 275, 172-83. PMID: 18070108 6. Pulkkinen, HH. et al. (2021) Angiogenesis 24, 129-144. PMID: 33021694
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human BMP6 Antibody (SAA0425), PerCP.pdf

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Anti-Human BMP6 Antibody (SAA0425), PerCP (HB857147)

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