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Anti-Human CD314/KLRK1 Antibody (SAA0098) (HB123107)

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Anti-Human CD314/KLRK1 Antibody (SAA0098)

Anti-Human CD314/KLRK1 Antibody (SAA0098)

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Overview

Catalog No.	HB123107
Description	Anti-Human CD314/KLRK1 Antibody (SAA0098) [SAA0098] (HB123107) is a human monoclonal antibody detecting KLRK1 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG4, kappa
Clone ID	SAA0098
Clonality	Monoclonal
Target	KLRK1, NKG2D, Killer cell lectin-like receptor subfamily K member 1, NKG2-D-activating NK receptor, D12S2489E, NKG2-D type II integral membrane protein, NK cell receptor D, CD314
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P26718
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	NKG2-D type II integral membrane protein (CD314/KLRK1) is a ~25 kDa protein. Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF.
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Anti-Human CD314/KLRK1 Antibody (SAA0098)

References

Datasheet

Anti-Human CD314/KLRK1 Antibody (SAA0098).pdf

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Anti-Human CD314/KLRK1 Antibody (SAA0098)