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InVivoMAb Anti-Mouse IL6 (MP5-20F3) (MY328020)

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InVivoMAb Anti-Mouse IL6 (MP5-20F3)

InVivoMAb Anti-Mouse IL6 (MP5-20F3)

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100ug
1mg

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Datasheet

Overview

Catalog No.	MY328020
Description	InVivoMAb Anti-Mouse IL6 (MP5-20F3) [MP5-20F3] (MY328020) is a rat monoclonal antibody detecting Interleukin-6 in ELISA, FACS, Functional assay, Research in vivo. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Mouse
Applications	ELISA, FACS, Functional assay, Research in vivo
Host species	Rat
Isotype	IgG1, kappa
Clone ID	MP5-20F3
Clonality	Monoclonal
Target	Interleukin-6, IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2, IL6, IFNB2
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P05231
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interleukin-6 (IL6) is a ~23 kDa protein. Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). IL6 is the therapeutic target of tocilizumab (Actemra).
Note	For research use only.

Images

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Mouse IL6 (MP5-20F3)

References

Datasheet

InVivoMAb Anti-Mouse IL6 (MP5-20F3).pdf

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InVivoMAb Anti-Mouse IL6 (MP5-20F3)