Anti-Human C9orf72 Antibody (SAA1886) (HA376013)

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100ug
1mg

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Datasheet

Overview

Catalog No.

HA376013

Description

Anti-Human C9orf72 Antibody (SAA1886) [SAA1886] (HA376013) is a mouse monoclonal antibody detecting C9orf72 in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1886

Clonality

Monoclonal

Target

Guanine nucleotide exchange C9orf72, C9orf72

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q96LT7

RRID

Anti-Human C9orf72 Antibody (SAA1886) (abinScience Cat# HA376013, RRID:AB_3727650)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro.

1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069

2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190

3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292

4. Jung, J. et al. (2017) eLife 6. PMID: 28195531

5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human C9orf72 Antibody (SAA1886)

References

Datasheet

Anti-Human C9orf72 Antibody (SAA1886).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human C9orf72 Antibody (SAA1886) (HA376013)

Overview

Images

References

Datasheet

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