Affiliations
Federica Vecchio, Alexia Carré, Daniil Korenkov, Zhicheng Zhou, Paola Apaolaza, Soile Tuomela, Orlando Burgos-Morales, Isaac Snowhite, Javier Perez-Hernandez, Barbara Brandao, Georgia Afonso, Clémentine Halliez, John Kaddis, Sally C Kent, Maki Nakayama, Sarah J Richardson, Joelle Vinh, Yann Verdier, Jutta Laiho, Raphael Scharfmann, Michele Solimena, Zuzana Marinicova, Elise Bismuth, Nadine Lucidarme, Janine Sanchez, Carmen Bustamante, Patricia Gomez, Soren Buus, Sylvaine You, Alberto Pugliese, Heikki Hyoty, Teresa Rodriguez-Calvo, Malin Flodstrom-Tullberg, Roberto Mallone
DOI: 10.1126/sciadv.adl1122
Abstract
Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell responses. β cells were efficiently infected by CVB in vitro, down-regulated human leukocyte antigen (HLA) class I, and presented few, selected HLA-bound viral peptides. Circulating CD8
Keywords
CD8，INF-α2a，T cell
