Apolipoprotein E4 and Alzheimer’s Disease: Pathogenic Mechanisms, Therapeutic Strategies, and Molecular Insights

Unlock groundbreaking insights into Alzheimer’s disease (AD) with abinscience’s high-quality APOE4 proteins, antibodies, and research tools. As the most common genetic risk factor for AD, APOE4 drives disease progression through lipid metabolism dysregulation, neuroinflammation, and blood-brain barrier (BBB) dysfunction—crucially linked to metabolic syndrome (MetS) and cognitive decline. At abinscience, we empower global researchers with premium APOE4 solutions, delivering unparalleled reliability, precision, and performance to accelerate discoveries in AD pathogenesis, drug development, and therapeutic innovation.

Advanced APOE4 Proteins & Antibodies for Cutting-Edge Alzheimer’s Research

APOE4 (Apolipoprotein E4) is a cornerstone in AD research, influencing lipid transport, neuroinflammation, and neuronal damage. abinscience offers a curated portfolio of high-purity recombinant proteins and monoclonal antibodies, meticulously designed to support advanced neuroscience studies, enabling precise insights into AD mechanisms, diagnostics, and therapeutic targets.

Fig .1.Schematic presentation of the apoE4-driven mechanisms involved in AD pathology

High-Purity APOE4 Proteins

Our APOE4 proteins are engineered for exceptional stability, activity, and reproducibility, making them ideal for basic, translational, and research applications:

• Recombinant Human APOE4 Protein, C-His (HF739011) – A C-terminal His-tagged recombinant human APOE4 protein, optimized for studying lipid metabolism, neuronal function, and AD pathology in vitro and in vivo. Ideal for lipid dysregulation and BBB function assays.
• Recombinant Human APOE4 Protein, N-Trx-His & C-His (HF739022) – Featuring N-terminal Trx and C-terminal His dual tags, this protein ensures enhanced purity and stability, perfect for structural biology, functional assays, and high-throughput drug screening targeting APOE4’s role in AD.

Each protein undergoes rigorous quality control, validated for activity, stability, and lot-to-lot consistency, ensuring reliable results for AD research worldwide.

Precision APOE4 Antibodies

Our antibodies target APOE4 with exceptional specificity, enabling accurate detection and functional studies in AD research:

• InVivoMAb Anti-Human APOE4 Antibody (HJ15.1) (HF739020) – A highly specific monoclonal antibody designed for in vivo and in vitro studies, ideal for neutralizing APOE4 activity, quantifying expression levels, and investigating its role in AD pathology, neuroinflammation, and lipid metabolism.

These antibodies are rigorously tested for sensitivity, specificity, and reproducibility, supporting researchers in exploring APOE4’s impact on β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and BBB integrity.

Powerful APOE4 Research Tools: Driving Alzheimer’s Discoveries

APOE4’s critical link to AD and MetS positions it as a key target for understanding neurodegenerative diseases. Our research tools are designed to accelerate breakthroughs in APOE4-related mechanisms, including:

• Lipid Metabolism Studies – Utilize our APOE4 proteins (HF739011, HF739022) to investigate how lipid dysregulation drives AD, focusing on cholesterol accumulation and BBB dysfunction.
• Neuroinflammation Research – Leverage our InVivoMAb Anti-Human APOE4 Antibody (HF739020) to study APOE4-induced inflammation and oxidative stress, key drivers of cognitive decline in AD.
• Therapeutic Development – Our products support drug screening, target validation, and biomarker discovery, facilitating the development of novel AD therapies targeting APOE4.

APOE4 in Alzheimer’s Disease: Mechanisms and Impact

Fig. 2. APOE4’s Role in Alzheimer’s Disease Pathology

APOE4 increases AD risk by promoting cholesterol accumulation in the brain, disrupting neuronal membrane stability, and triggering chronic neuroinflammation. It also compromises BBB function, allowing peripheral lipids to enter the brain, exacerbating AD pathology through β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs).

APOE4 Research Products:

Why Choose abinscience for Your APOE4 Research?

abinscience’s APOE4 proteins, antibodies, and research tools stand out as industry leaders, offering:

• Unmatched Quality – Each product is stringently tested for activity, stability, and lot-to-lot consistency, ensuring reliable results for critical AD research.
• Superior Precision – Engineered for reproducible outcomes across diverse experimental settings, from basic research to clinical trials, trusted by top labs globally.
• Global Trust – Featured on leading databases like CiteAb and Biocompare, our products are used by researchers worldwide to drive AD breakthroughs.

Elevate your APOE4 and Alzheimer’s disease research with abinscience’s trusted, high-performance tools. Our solutions empower you to uncover new insights into neurodegeneration, lipid metabolism, and therapeutic innovation—faster and with greater confidence.

Discover abinscience APOE4 Products Now!