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Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229) (VK565566)

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Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)

Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)

Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)

Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)

Цена(USD): $

Спецификация:

100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит

Обзор

Каталожный номер	VK565566
Описание	Anti-SARS-CoV-2 RBD Antibody (VIR-7229) (VK565566) is a research-grade recombinant antibody targeting Receptor-Binding Domain. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	SARS-CoV-2
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Изотип	IgG1-kappa
ID клона	VIR-7229
Система экспрессии	Mammalian Cells
Цель	Receptor-Binding Domain, RBD, Spike glycoprotein, S glycoprotein, Peplomer protein, Spike protein S1, S
Уровень эндотоксинов	Please contact the lab for this information.
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P0DTC2
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Альтернативные названия	VIR-7229, VIR7229, VIR7229
Фон	Spike glycoprotein (RBD) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant SARS-CoV-2 RBD(Catalog No: VK565131)
Lane 2: negative control

Ссылки

Даташит

Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229).pdf

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Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)