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Research Grade Tamgiblimab (HS739066)

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Research Grade Tamgiblimab

Research Grade Tamgiblimab

Research Grade Tamgiblimab

Research Grade Tamgiblimab

Цена(USD): $

Спецификация:

100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит

Обзор

Каталожный номер	HS739066
Описание	Tamgiblimab (HS739066) is a research-grade recombinant antibody targeting VSTM3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Изотип	IgG4-kappa
Система экспрессии	Mammalian Cells
Клоональность	Monoclonal
Цель	VSTM3, TIGIT, V-set and transmembrane domain-containing protein 3, VSIG9, V-set and immunoglobulin domain-containing protein 9, T-cell immunoreceptor with Ig and ITIM domains
Уровень эндотоксинов	Please contact the lab for this information.
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q495A1
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Альтернативные названия	IBI939, IBI-939, IBI939
Фон	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. 1. Yu, X. et al. (2009) Nature immunology 10, 48-57. PMID: 19011627 2. Liu, S. et al. (2013) Cell death and differentiation 20, 456-64. PMID: 23154388 3. Li, M. et al. (2014) The Journal of biological chemistry 289, 17647-57. PMID: 24817116 4. Reches, A. et al. (2020) Journal for immunotherapy of cancer 8. PMID: 32503945
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

Bioactivity

Detects TIGIT in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Tamgiblimab.

Ссылки

Даташит

Research Grade Tamgiblimab.pdf

Formula

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Formula

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Working Solution

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Список дистрибьюторов

Research Grade Tamgiblimab