Anti-Durvalumab Neutralizing Antibody ELISA kit (AV974518)

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Каталожный номер	AV974518
Описание	Anti-Durvalumab Neutralizing Antibody ELISA kit (AV974518) — Quantitative sandwich ELISA for Anti-Durvalumab Neutralizing Antibody. Sample: Plasma, Serum. Range: 15.625-1, 000 ng/ml. Highlights ●Sandwich Format — High specificity, reliable quantification. ●Ready-to-Use — Complete kit with pre-coated plates included.
Применения	ELISA
Номер доступа	Q9NZQ7
Метод обнаружения	Colorimetric
Тип образца	Plasma, Serum
Тип анализа	Quantitative
Диапазон	15.625-1, 000 ng/ml
Восстановление	80-120%
Доставка	2-8 ℃
Устойчивость и хранение	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
Характеристики	Durvalumab
Альтернативные названия	MEDI4736, 1428935-60-7
Фон	Programmed cell death 1 ligand 1 (Durvalumab) is a ~33 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. 1. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443 2. Mezzadra, R. et al. (2017) Nature 549, 106-110. PMID: 28813410 3. Burr, ML. et al. (2017) Nature 549, 101-105. PMID: 28813417 4. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419 5. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298 6. Dong, H. et al. (1999) Nature medicine 5, 1365-9. PMID: 10581077 7. Hou, J. et al. (2020) Nature cell biology 22, 1264-1275. PMID: 32929201
Примечание	For Research Use Only.