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Anti-Human CD38/ADPRC 1 Antibody (SAA2211), APC (HB691637)

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Anti-Human CD38/ADPRC 1 Antibody (SAA2211), APC

Anti-Human CD38/ADPRC 1 Antibody (SAA2211), APC

Цена(USD): $

Спецификация:

50T
100T

Количество:

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Даташит

Обзор

Каталожный номер	HB691637
Описание	Anti-Human CD38/ADPRC 1 Antibody (SAA2211), APC [SAA2211] (HB691637) is a human monoclonal antibody detecting ADPRC 1 in ELISA, FCM. Suitable for Human. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Реактивность видов	Human
Применения	ELISA, FCM
Хозяинский вид	Human
Изотип	IgG1, lambda
ID клона	SAA2211
Конъюгация	APC
Клоональность	Monoclonal
Цель	Cyclic ADP-ribose hydrolase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, T10, 2'-phospho-cyclic-ADP-ribose transferase, CD38, ADPRC 1, ADP-ribosyl cyclase 1, 2'-phospho-ADP-ribosyl cyclase
Уровень эндотоксинов	Please contact with the lab for this information.
Очистка	Affinity chromatography.
Номер доступа	P28907
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38/ADPRC 1) is a ~34 kDa protein. Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. CD38 is the therapeutic target of daratumumab (Darzalex). 1. Tohgo, A. et al. (1994) The Journal of biological chemistry 269, 28555-7. PMID: 7961800 2. Takasawa, S. et al. (1993) The Journal of biological chemistry 268, 26052-4. PMID: 8253715 3. Moreschi, I. et al. (2006) Biochemical and biophysical research communications 345, 573-80. PMID: 16690024 4. Deaglio, S. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 395-402. PMID: 9551996 5. Frasca, L. et al. (2006) Blood 107, 2392-9. PMID: 16293598 6. Deaglio, S. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 580-2. PMID: 11259373
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Изображения

Flow Cytometry

Flow-cytometry using APC anti-Human CD38 antibody. RPMI-8226 cells were stained with an irrelevant antibody (Green Histogram) or an APC anti-Human CD38 antibody monoclonal antibody (Catalog # HB691637 , Red Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

Ссылки

Даташит

Anti-Human CD38/ADPRC 1 Antibody (SAA2211), APC.pdf

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Anti-Human CD38/ADPRC 1 Antibody (SAA2211), APC