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Anti-Human CD19 Antibody (SAA0005), APC (HB996137)

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Anti-Human CD19 Antibody (SAA0005), APC

Anti-Human CD19 Antibody (SAA0005), APC

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100T

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Обзор

Каталожный номер	HB996137
Описание	Anti-Human CD19 Antibody (SAA0005), APC [SAA0005] (HB996137) is a human monoclonal antibody detecting CD19 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Human
Изотип	IgG1, kappa
ID клона	SAA0005
Конъюгация	APC
Клоональность	Monoclonal
Цель	CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4
Уровень эндотоксинов	Please contact with the lab for this information.
Номер доступа	P15391
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	B-lymphocyte antigen CD19 is a ~61 kDa protein. Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. CD19 is the therapeutic target of tafasitamab (Monjuvi). 1. Vanshylla, K. et al. (2018) Scientific reports 8, 4244. PMID: 29523808 2. Carter, RH. et al. (1992) Science (New York, N.Y.) 256, 105-7. PMID: 1373518 3. van Zelm, MC. et al. (2006) The New England journal of medicine 354, 1901-12. PMID: 16672701 4. de Rie, MA. et al. (1989) Cellular immunology 118, 368-81. PMID: 2463100 5. Wang, Y. et al. (2002) Immunity 17, 501-14. PMID: 12387743 6. Sato, S. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 3278-87. PMID: 9317126 7. Buhl, AM. et al. (1997) The Journal of experimental medicine 186, 1897-910. PMID: 9382888
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Изображения

Flow Cytometry

Flow-cytometry using APC anti-human CD19 antibody. Raji cells were stained with an irrelevant antibody (Green Histogram) or an APC anti-human CD19 antibody monoclonal antibody (Catalog # HB996137, Red Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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Даташит

Anti-Human CD19 Antibody (SAA0005), APC.pdf

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Anti-Human CD19 Antibody (SAA0005), APC