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Anti-Human CD38/ADPRC 1 Antibody (OKT10) (HB691407)

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Anti-Human CD38/ADPRC 1 Antibody (OKT10)

Anti-Human CD38/ADPRC 1 Antibody (OKT10)

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Спецификация:

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100ug

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Каталожный номер	HB691407
Описание	Anti-Human CD38/ADPRC 1 Antibody (OKT10) [OKT10] (HB691407) is a rabbit monoclonal antibody detecting ADPRC 1 in FCM. Suitable for Human. Highlights ●Rabbit Monoclonal — High specificity, affinity, and excellent lot-to-lot consistency. ●Flow Cytometry — Validated for flow cytometry applications.
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Rabbit
Изотип	IgG
ID клона	OKT10
Клоональность	Monoclonal
Цель	Cyclic ADP-ribose hydrolase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, T10, 2'-phospho-cyclic-ADP-ribose transferase, CD38, ADPRC 1, ADP-ribosyl cyclase 1, 2'-phospho-ADP-ribosyl cyclase
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P28907
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.09% Sodium azide. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38/ADPRC 1) is a ~34 kDa protein. Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. CD38 is the therapeutic target of daratumumab (Darzalex). 1. Tohgo, A. et al. (1994) The Journal of biological chemistry 269, 28555-7. PMID: 7961800 2. Takasawa, S. et al. (1993) The Journal of biological chemistry 268, 26052-4. PMID: 8253715 3. Moreschi, I. et al. (2006) Biochemical and biophysical research communications 345, 573-80. PMID: 16690024 4. Deaglio, S. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 395-402. PMID: 9551996 5. Frasca, L. et al. (2006) Blood 107, 2392-9. PMID: 16293598 6. Deaglio, S. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 580-2. PMID: 11259373
Примечание	For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human CD38/ADPRC 1 Antibody (OKT10)

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Anti-Human CD38/ADPRC 1 Antibody (OKT10).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Volume

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Formula

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Stock Solution

C₁ (Stock Conc.)

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V₁ (Stock Vol.)

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Working Solution

C₂ (Working Conc.)

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Anti-Human CD38/ADPRC 1 Antibody (OKT10)