

| Каталожный номер | HF004093 | ||||
|---|---|---|---|---|---|
| Описание |
Anti-EGFR scFv Antibody (SAA2244) [SAA2244] (HF004093) is a human monoclonal antibody detecting EGFR in ELISA. Suitable for Human.
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| Реактивность видов | Human | ||||
| Применения | ELISA | ||||
| Хозяинский вид | Human | ||||
| Изотип | scFv-His | ||||
| ID клона | SAA2244 | ||||
| Система экспрессии | Mammalian Cells | ||||
| Виды | Human | ||||
| Клоональность | Monoclonal | ||||
| Цель | EGFR | ||||
| Специфичность | Human | ||||
| Чистота | >95% purity as determined by SDS-PAGE. | ||||
| Номер доступа | P00533 | ||||
| RRID | Anti-EGFR scFv Antibody (SAA2244) (abinScience Cat# HF004093, RRID:AB_3730100) |
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| Форма | Liquid | ||||
| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. | ||||
| Альтернативные названия | Epidermal growth factor receptor, EC:2.7.10.1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR | ||||
| Фон | Epidermal growth factor receptor (EGFR) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. 1. Arcaro, A. et al. (2000) Molecular and cellular biology 20, 3817-30. PMID: 10805725 2. Runkle, KB. et al. (2016) Molecular cell 62, 385-396. PMID: 27153536 3. Chen, WS. et al. (1989) Cell 59, 33-43. PMID: 2790960 4. Bu, J. et al. (2022) Acta biochimica et biophysica Sinica 54, 400-408. PMID: 35538033 5. Garrett, TP. et al. (2002) Cell 110, 763-73. PMID: 12297049 6. Kochupurakkal, BS. et al. (2005) The Journal of biological chemistry 280, 8503-12. PMID: 15611079 7. Kim, J. et al. (2007) Cancer research 67, 9229-37. PMID: 17909029 8. Lu, C. et al. (2010) Molecular and cellular biology 30, 5432-43. PMID: 20837704 | ||||
| Примечание | For research use only. |

SDS-PAGE for Anti-EGFR scFv Antibody (SAA2244)
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