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Anti-EGFR scFv Antibody (SAA2244)
Anti-EGFR scFv Antibody (SAA2244)
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Цена(USD): $
Спецификация:
  • 20ug
  • 50ug
  • 100ug
  • 1mg
Количество:
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Обзор
Каталожный номерHF004093
Описание
Anti-EGFR scFv Antibody (SAA2244) [SAA2244] (HF004093) is a human monoclonal antibody detecting EGFR in ELISA. Suitable for Human.
Реактивность видовHuman
ПримененияELISA
Хозяинский видHuman
ИзотипscFv-His
ID клонаSAA2244
Система экспрессии Mammalian Cells
Виды Human
Клоональность Monoclonal
Цель EGFR
Специфичность Human
Чистота >95% purity as determined by SDS-PAGE.
Номер доступа P00533
RRID Anti-EGFR scFv Antibody (SAA2244) (abinScience Cat# HF004093, RRID:AB_3730100)
Форма Liquid
Информация об использовании продукта
Применение Разбавление
ELISA 1:2000-1:20000
Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Альтернативные названияEpidermal growth factor receptor, EC:2.7.10.1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR
Фон

Epidermal growth factor receptor (EGFR) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.

1. Arcaro, A. et al. (2000) Molecular and cellular biology 20, 3817-30. PMID: 10805725
2. Runkle, KB. et al. (2016) Molecular cell 62, 385-396. PMID: 27153536
3. Chen, WS. et al. (1989) Cell 59, 33-43. PMID: 2790960
4. Bu, J. et al. (2022) Acta biochimica et biophysica Sinica 54, 400-408. PMID: 35538033
5. Garrett, TP. et al. (2002) Cell 110, 763-73. PMID: 12297049
6. Kochupurakkal, BS. et al. (2005) The Journal of biological chemistry 280, 8503-12. PMID: 15611079
7. Kim, J. et al. (2007) Cancer research 67, 9229-37. PMID: 17909029
8. Lu, C. et al. (2010) Molecular and cellular biology 30, 5432-43. PMID: 20837704
Примечание For research use only.
Изображения
  • Anti-EGFR scFv Antibody (SAA2244)

    SDS-PAGE

    SDS-PAGE for Anti-EGFR scFv Antibody (SAA2244)

Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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