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| カタログ番号 | HB651011 |
|---|---|
| 説明 |
Recombinant Human CD152/CTLA4 Protein, C-His (HB651011) expressed in Mammalian Cells, spanning Met1-Asp161. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | Mammalian Cells |
| アクセッション番号 | P16410 |
| タンパク質長 | Met1-Asp161 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 18.55 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CD152, Cytotoxic T-lymphocyte protein 4, CTLA-4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4 |
| 背景 | Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy). 1. Schwartz, JC. et al. (2001) Nature 410, 604-8. PMID: 11279501 2. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502 3. Teft, WA. et al. (2006) Annual review of immunology 24, 65-97. PMID: 16551244 4. Linsley, PS. et al. (1991) The Journal of experimental medicine 174, 561-9. PMID: 1714933 5. Zheng, Y. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1683-91. PMID: 18641304 6. Ramagopal, UA. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E4223-E4232. PMID: 28484017 |
| 注意事項 | For research use only. |
SDS-PAGE for Recombinant Human CD152/CTLA4 Protein, C-His
Detects Human CD152/CTLA4 Antibody in indirect ELISAs.
Detects Ipilimumab in indirect ELISAs.
Detects Nurulimab in indirect ELISAs.
Detects Cadonilimab in indirect ELISAs.
Detects Botensilimab in indirect ELISAs.
Detected by Research Grade Gotistobart (Cat No.: HB651266) in indirect ELISA.
Detected by Anti-CD152/CTLA4 monoclonal antibody (Catalog No: HS870396)
Detected by Research Grade Quavonlimab (Catalog No: HB651066) in indirect ELISA
Detected by Anti-Human CD152/CTLA4 Antibody (HL32) (Catalog No: HB651407) in indirect ELISA
Detected by SAA1104 (Catalog No: HB651013) in indirect ELISA.
Detected by Pavunalimab (Catalog No: HB613086) in indirect ELISA.
Detected by Lorigerlimab (Catalog No: HB651086) in indirect ELISA.
Detected by Tuvonralimab (Catalog No: HB651096) in indirect ELISA.
Detected by Porustobart (Catalog No: HB651246) in indirect ELISA.
Detected by Firastotug (Catalog No: HB651256) in indirect ELISA.
Detected by Muzastotug (Catalog No: HB651276) in indirect ELISA.
Detected by Sovipostobart (Catalog No: HB651286) in indirect ELISA.
Detected by Evalstotug (Catalog No: HB651296) in indirect ELISA.
Detected by Vilastobart (Catalog No: HB651306) in indirect ELISA.
Detected by Tazlestobart (Catalog No: HB651316) in indirect ELISA.
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