Research Grade Anti-Human CD160 (MAT 303) (HF985016)

データシート製品共有情報コピー

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100ug
1mg

数量:

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概要
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参考文献
データシート

概要

カタログ番号	HF985016
説明	Anti-Human CD160 (MAT 303) (HF985016) is a research-grade recombinant antibody targeting CD160. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
アイソタイプ	IgG
クローンID	MAT 303
発現システム	Mammalian Cells
クローン性	Monoclonal
ターゲット	Natural killer cell receptor BY55, CD160 antigen, CD160, BY55
エンドトキシンレベル	Please contact the lab for this information.
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	O95971
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
別名	MAT-303, MAT303, MAT303
背景	CD160 antigen is a ~19 kDa protein. Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells. 1. Nikolova, M. et al. (2002) International immunology 14, 445-51. PMID: 11978774 2. Rabot, M. et al. (2007) International immunology 19, 401-9. PMID: 17307798 3. Giustiniani, J. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 63-71. PMID: 19109136 4. Le Bouteiller, P. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16963-8. PMID: 12486241 5. Agrawal, S. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 162, 1223-6. PMID: 9973372 6. Viganò, S. et al. (2014) PLoS pathogens 10, e1004380. PMID: 25255144 7. Fons, P. et al. (2006) Blood 108, 2608-15. PMID: 16809620 8. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050
注意事項	For research use only. Not suitable for clinical or therapeutic use.