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Anti-Human FCGRT/FCRN Antibody (SAA0136) (HX061207)

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Anti-Human FCGRT/FCRN Antibody (SAA0136)

Anti-Human FCGRT/FCRN Antibody (SAA0136)

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概要

カタログ番号	HX061207
説明	Anti-Human FCGRT/FCRN Antibody (SAA0136) [SAA0136] (HX061207) is a human monoclonal antibody detecting FCGRT in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
種反応性	Human
アプリケーション	FCM
宿主種	Human
アイソタイプ	IgG4, kappa
クローンID	SAA0136
クローン性	Monoclonal
ターゲット	IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P55899
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	IgG receptor FcRn large subunit p51 (FCGRT) is a ~39 kDa protein. Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. 1. West, AP. et al. (2000) Biochemistry 39, 9698-708. PMID: 10933786 2. Story, CM. et al. (1994) The Journal of experimental medicine 180, 2377-81. PMID: 7964511 3. Mikulska, JE. et al. (2000) European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 27, 231-40. PMID: 10998088 4. Oganesyan, V. et al. (2014) The Journal of biological chemistry 289, 7812-24. PMID: 24469444 5. Pyzik, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2862-E2871. PMID: 28330995
注意事項	For research use only.

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SDS-PAGE

SDS-PAGE for Anti-Human FCGRT/FCRN Antibody (SAA0136)

参考文献

データシート

Anti-Human FCGRT/FCRN Antibody (SAA0136).pdf

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Anti-Human FCGRT/FCRN Antibody (SAA0136)